Wegovy vs Zepbound: Which Is Right for Weight Loss?
Both are FDA-approved for weight loss but use different drugs. Here is the honest, plain comparison.
The short answer
Wegovy is semaglutide (Novo Nordisk); Zepbound is tirzepatide (Eli Lilly). Both are FDA-approved for chronic weight management, but Zepbound works on two appetite-hormone pathways (GIP and GLP-1) while Wegovy works on one (GLP-1). In trials of the brand drugs, tirzepatide produced larger average weight loss.
Quick comparison
| Feature | Wegovy | Zepbound |
|---|---|---|
| Active ingredient | Semaglutide | Tirzepatide |
| Maker | Novo Nordisk | Eli Lilly |
| FDA-approved for | Chronic weight management | Chronic weight management, also obstructive sleep apnea |
| How it is taken | Injection | Injection |
| Hormone pathways | GLP-1 only | GIP and GLP-1 |
| At New Hope Weight Loss | Compounded semaglutide from $166 a month, not FDA-approved or brand-identical | Compounded tirzepatide from $233 a month, not FDA-approved or brand-identical |
The trial numbers
Wegovy (semaglutide 2.4 mg) averaged about 14.9% body-weight loss at 68 weeks in STEP 1 (PMID 33567185). Zepbound (tirzepatide 15 mg) averaged about 20.9% at 72 weeks in SURMOUNT-1 (PMID 35658024). These studied the brand drugs; individual results vary.
Ready to start?
$199 Skeptics' Trial, see if it works for you
One-time $199 trial with physician evaluation and, only if a prescription is approved and the dispensing pharmacy can fulfill it for the patient's location, one month of compounded semaglutide; the pharmacy confirms packaging and shipping details before fulfillment. No long-term commitment. Standard care starts with a $119 physician review; medication is separate, and compounded semaglutide programs start at $166/month.
Start the 30-day trialHow to choose
Higher average loss is not automatically the right choice for you. Tolerability, side effects, cost, other conditions, and your history all matter, which is why a physician decides. Zepbound is also FDA-approved for obstructive sleep apnea in adults with obesity.
How this relates to what we offer
We do not dispense Wegovy or Zepbound. The dispensing pharmacy label identifies the compounded preparation as semaglutide or tirzepatide. It is a different product from FDA-approved brands, is not FDA-approved or brand-identical, and results vary.
What you can start today at New Hope Weight Loss
After a one-time $119 medical review with Dr. Sharma, eligible patients begin physician-supervised compounded semaglutide from $166 a month or compounded tirzepatide from $233 a month, with a $199 one-month Skeptics' Trial. Compounded semaglutide and tirzepatide are not FDA-approved or brand-identical and have not undergone FDA premarket review for safety, effectiveness, or quality. Results vary. Any prescription depends on individualized medical review and lawful pharmacy fulfillment for the patient's location. In person in Orange County and by telehealth for eligible patients in California.
Frequently asked questions
Is Zepbound stronger than Wegovy?
In brand trials, tirzepatide (Zepbound) produced larger average weight loss (about 20.9%) than semaglutide (Wegovy, about 14.9%). It works on two hormone pathways. The right choice still depends on your situation, tolerability, and cost.
Are Wegovy and Zepbound the same drug?
No. Wegovy is semaglutide; Zepbound is tirzepatide. Both are FDA-approved for weight management but are different molecules from different companies.
Which has fewer side effects?
Both are mostly gastrointestinal and usually transient. Individual tolerance varies; a physician helps you weigh it.
Does New Hope offer Wegovy or Zepbound?
We do not dispense the brand products. We offer physician-supervised compounded semaglutide and tirzepatide (not FDA-approved or brand-identical) after a $119 review.
Which is cheaper?
Brand pricing varies; both can be expensive without coverage. Our compounded semaglutide starts at $166/mo and tirzepatide at $233/mo after a $119 review.
This article is informational only and not medical advice. Speak with a licensed physician before starting or changing any GLP-1 therapy. Individual results vary. New Hope Weight Loss is a physician-supervised medical weight loss clinic in Costa Mesa, CA. Eligibility for treatment is determined during the medical consultation. Compounded semaglutide and compounded tirzepatide are not the same products as Wegovy®, Ozempic®, Mounjaro®, or Zepbound®.